The empty heart containers will replace any other heart containers if the maximum has been reached. Eyes and other similar enemies, however, will still target Isaac. Most enemies now target the heart instead of Isaac. … Enemies that come in contact with Isaac take x2 Isaac’s current damage over 2-3 ticks per second. What does the heart do in binding of Isaac? The heart charges up as Isaac fires. In order for Isaac to pick up Red Hearts, he must have Heart Containers that can be gained from a number of “Health Up” collectables or through completion of an Eternal Heart. How do you get heart containers binding of Isaac? Empty Red Heart containers can be refilled with Red Heart pickups. If the player has only Red Hearts, the containers will be unfilled as damage is taken (but the containers themselves remain). Red Heart containers, or Red Hearts, are the main form of health for the majority of characters.
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